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In injection form, higher concentrations can occasionally trigger mild gastrointestinal symptoms nausea, loose stools, or a feeling of stomach heaviness in people who are sensitive to it or who are new to the formula

Nature 418 , 650654 (2002)

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TRPV1 Channel Inhibition: Research published in Molecular Immunology (2023) identified a second direct analgesic mechanism ARA-290 specifically inhibits TRPV1 (Transient Receptor Potential Vanilloid 1) channel activity in peripheral nociceptors, increasing the pain threshold and relieving mechanical hypersensitivity independent of its anti-inflammatory IRR actions