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Areas of scientific research interest have included: NAD metabolism and NNMT-pathway studies Obesity- and adipose-tissue regulation research Mitochondrial-function and metabolic-syndrome investigations Insulin-sensitivity and glucose-homeostasis research Longevity-, healthy-aging-, and cellular-maintenance studies Cellular-energy and metabolic-regulation pathways Oxidative-stress and mitochondrial-related research models 5-Amino-1MQ has been investigated in biochemical, metabolic, and cellular research models focused on energy regulation, mitochondrial-related pathways, and metabolic function

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Those with diseases that affect the gut, such as Crohns disease or celiac disease, are also at risk ( Summary Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet