[DOI] [PMC free article] [PubMed] [Google Scholar] 165.Marton L.T., Pescinini-e-Salzedas L.M., Camargo M.E.C., Barbalho S.M., Haber J.F., dos S., Sinatora R.V., Detregiachi C.R.P., Girio R.J.S., Buchaim D.V., Cincotto dos Santos Bueno P
New insights into the roles of CHOP-induced apoptosis in ER stress
With respect to the substantial similarity criteria, the applicant asserted that SeptiCyte RAPID is not substantially similar to other currently available technologies because SeptiCyte RAPID differs in mechanism, performance, and turnaround time from all current sepsis diagnostic tools by leveraging the host's immune response to systemic inflammation of infectious origin via measurement of the gene expression ratio between upregulated and downregulated genes, and therefore, the technology meets the newness criterion
Discussion As one of the most complex biological processes that occur during human life, the wound repair process involves four steps that include inflammation around the site of injury, angiogenesis and the development of granulation tissue, repair of the connective tissue and epithelium, and ultimately remodeling that leads to a healed wound.1 The clinical treatment of skin loss due to severe and massive burns or wounds continues to be a major problem in surgical procedures
