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Choline in the methylation cycle: Doctors and researchers first realized that adequate folate reduced the incidence of neural tube defects such as spina bifida

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Phytate is the main form of phosphate in natural sources, and its dietary intake is associated with the development of insoluble complexes with calcium within the gut, which can cause suppression of crystal formation in the urine and decrease the risk of urolithiasis [14,19]

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