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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, and Impairment of Fertility Carcinogenesis Valproate was administered orally to rats and mice at doses of 80 and 170 mg/kg/day (less than the maximum recommended human dose on a mg/m 2 basis) for two years

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Phytanic acid is first converted to its CoA-ester and then phytanoyl-CoA serves as a substrate in an -oxidation process, therefore, the process is referred to as -oxidation (Figure 25-6)