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2,6 Specific variations in DAT1 (SLC6A3) and catechol-O-methyltransferase (COMT) expression or activity have been hypothesized to indicate altered catecholamine turnover and disrupted dopaminergic signaling, while changes in tryptophan hydroxylase (TPH) may affect serotonergic neurotransmission, potentially contributing to the characteristic symptoms of ADHD

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