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(2022) observed that although a two-month synbiotic intervention consisting of 510 9 CFU Lactobacillus acidophilus and Bifidobacterium longum and 60 mg of FOS in a double-blinded randomized controlled clinical trial involving hemodialysis patients with gastrointestinal complaints had a substantial effect in improving constipation and general quality of life in the synbiotic group, it did not reduce the levels of IS in their serum compared to the placebo group

PubMed Alba, M., Fintini, D., Bowers, C.Y., & Salvatori, R