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Role in the Body & Energy Production Vitamin B plays several vital roles that underlie its effect on energy and vitality: Red blood cell (RBC) production: B12 is needed for DNA synthesis in bone marrow
J Clin Invest 122:15741583 McGill MR, Cao M, Svetlov A, Sharpe MR, Williams CD, Curry SC, Farhood A, Jaeschke H, Svetlov SI (2014a) Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans
More recently, hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have received clinical approval for their ability to promote hematopoiesis through enhancing endogenous EPO production (McCallum et al., 2022)
[5] Emerging pharmacokinetic modeling and clinical trials demonstrate that individualized combination dosing anchored to residual thyroid output, sex, and body mass may normalize serum free-T3 to free-T4 ratios more consistently than T4 monotherapy
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