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doi: 10.1016/j.intimp.2015.11.026 32 TanSXuJLaiACuiRBaiRLiSet al

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These cytokines engage microglial Toll-like receptors (TLRs), particularly TLR4, triggering chronic neuroinflammation and subsequent neuronal injury

The immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, accounting for the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation (155)