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78 The emergence of artificial intelligence (AI), machine learning, and deep learning has revolutionized peptide design, placing these technologies at the forefront of computational approaches

ACPs design strategies, such as hybridization, cyclization, modification, and fragmentation, can potentially improve the therapeutic efficacy by extending the half-life time of medications in plasma, boosting activity, and minimizing drug toxicity (154)

Pharmacokinetic parameters after intravenous administration in rats showed Dihexa possessed a long half-life of 12.68 days and was extensively distributed, indicated by a large volume of distribution (Va)

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