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In the OASIS-1 study, 13% of participants (people with obesity without diabetes) receiving oral semaglutide 50 mg experienced altered skin sensation events compared to 1% with placebo - these events were generally mild to moderate in severity, occurred during dose escalation to the higher doses and resolved without requiring permanent treatment discontinuation [21]

Dont use it if you develop itching, severe rash, or blistering

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

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