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Your metabolism gets what it needs to get better energy from what you eat
He received his BS from Texas Tech University and resides in Houston with his wife and two daughters
Proc Natl Acad Sci USA 105(28):98419846
It was well established that the hepatotoxicity of APAP begins with the metabolic conversion of APAP to its reactive metabolite (N/-acetyl-p-benzoquinone imine, or NAPQI) ( CYP2E1 catalyzes the oxidation of APAP to NAPQI, a highly reactive metabolite inducing severe massive hepatocellular necrosis ( CYP2E1 knockout mice showed resistance to the APAP high dose-associated hepatotoxicity, suggesting that CYP2E1 is the major cytochrome P450 enzyme participating in APAP metabolism and toxicity ( CYP2E1 in APAP toxicity, CYP enzymes, notably CYP2E1 , generate ROS and lipid peroxidation ( As CYP2E1 is the major source of NAPQI, an evaluation of the CYP2E1 expression level was done in this study
