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Sleepwake cycle In the 1990s, a number of trials were carried out into the effects of B12 on circadian rhythm and the sleepwake cycle, but no more recent studies have been published on this topic

Preclinical Safety Evaluation In preclinical studies, BPC 157 did not lead to any serious toxicity in tested animals, including: mice rats rabbits dogs These studies provide a strong foundation for understanding the safety profile of BPC 157, indicating that it is well-tolerated across different species

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That does not necessarily mean it is proven to rebuild injured tendons in people, but it does explain why interest in the peptide remains high