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Upon receipt, the vials should be stored in a cool, dry place, ideally at -20C for long-term preservation

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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

Thus, from a scientific point of view, dietary supplements are urgently recommended for this group of people