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Sikora E, Bielak-Zmijewska A, Dudkowska M, Krzystyniak A, Mosieniak G, Wesierska M, Wlodarczyk J (2021) Cellular senescence in brain aging

445 The theory behind this clock of aging is that the blood levels of particular immune cells and proteins change with age

in biological terms it performs a cell protective activity in biological tissues through its antioxidant action and as a combination agent for metabolites to be disposed of by the organism

When oocytes experience DNA damage due to chemotherapy, radiotherapy, environmental toxins, or natural aging, members of the p53 family, particularly the TAp63 isoform, are activated