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Post-translational Modification During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine

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Additionally, when DNA repair is impaired as a consequence of mutations in the gene coding for the tumour suppressor Breast Cancer 2 ( BRCA2) , environmental FA can drive genome instability and contribute with cancer initiation 12

Collectively, our data strongly indicates that the eryptosis inducers benzethonium, oridonin and amiodarone have antiparasitic effects that are independent of eryptosis induction ( Table 2 )