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Although PPV was considered an attractive strategy for PCa, and even after successful phase II trials, the phase III trial of 310 patients with mCRPC receiving docetaxel found no survival advantage over PBO (HR 1.04

Most data comes from: That said, Dihexa is being used off-label in clinical practices, and practitioners continue to monitor real-world outcomes in: Despite promising data, Dihexa has not yet completed the rigorous phases needed for FDA approval

There are several explanations for these positive effects of the hexapeptide and related analogues on cognition available in the literature