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This inhibition reduces hepatic inflammation, which is implicated in the progression of liver steatosis to steatohepatitis and fibrosis

In the 48-week Phase 2 MASH trial (NCT04771273) published in the New England Journal of Medicine, histologic improvement in MASH without worsening of fibrosis occurred in up to 62% of survodutide-treated participants (at 4.8 mg) versus 14% on placebo, with a significant dose-response