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477 , Adding further complexity, the vast majority of death certificates listing Alzheimer's disease as an underlying cause of death are not verified by autopsy, and research has shown that 15% to 30% of those diagnosed with Alzheimer's dementia during life do not have the brain changes of Alzheimer's disease but instead have the brain changes of another cause of dementia (see Table 1)

However, outcomes may also depend on genetic predisposition to inflammation

NUPR1 The stress response gene, nuclear protein 1, transcriptional regulator (NUPR1) is a multifunctional stress-inducing protein, which is produced under a variety of environmental pressures, including oxidative damage and unfolded protein response

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