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The scope of research on this compound is currently limited to preclinical studies, with an absence of clinical data

In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]

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This study showed that a short course of sublingual vitamin B12, 1000 mcg daily, can significantly improve the severity of fibromyalgia as well as the anxiety score of fibromyalgia patients, the authors wrote, adding that there was no improvement in depression scores or health status scales