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Borrajo A, Prez-Rodrguez D, Fernndez-Pereira C, Prieto-Gonzlez JM, Ags-Balboa RC

Dysbiosis of the microbiome forms a new internal environment, under which it may affect the development of GERD from the perspectives of molecular mechanisms: microbial activation of Toll-like receptors, microbial stimulation of cyclooxygenase-2 expression, microbial stimulation of inducible nitrous oxide synthase, and activation of the NLRP3 inflammatory vesicle

There are two types of bipolar disorder, Type I involves severe episodes of mania and depression, and Type II includes episodes of hypomania and depression (Andreazza et al