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Laboratory studies demonstrate that elimination of senescent cells through FOXO4-DRI administration can break the cycle of senescence induction and chronic inflammation, offering insights into interventions for age-related cellular dysfunction and tissue deterioration

Abbreviations Supplementary Materials The following are available online at Table S1: Grading of Recommendations Assessment, Development, and Evaluation (GRADE) of selected studies

The penetration of nanocarriers was followed from the donor (upper) to the acceptor (lower) compartment mimicking blood to brain direction

Many molecules involved in establishing the senescence cell fate also play critical roles in cell survival or apoptosis pathways