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Additionally, its mRNA expression was observed in peripheral tissues such as the adrenal cortex, testis, pancreas, heart, and lung ( The expression of ghrelin receptor mRNA is suppressed by GH but stimulated by GHRH ( The ghrelin receptor also has a splice variant known as GHS-R1b, comprising only five transmembrane helices

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Hydroxyl radical is an extremely reactive oxidant, which are generated as a result of interaction of H 2 O 2 with transition metal ions such as Fe 2+ or Cu 2+ (Fenton reaction) and O 2 (Haber-Weiss reaction) as well as from peroxynitrite which is rapidly formed via the reaction between NO and O 2 Hydrogen peroxide is formed through dismutation of O 2 catalyzed by the enzyme superoxide dismutase, and is also produced by several other oxidase enzymes (e.g