when the research objectives allow it, used non-lethal sampling techniques instead of lethal collecting, and used preferential collection of post reproductive individuals (or the life stage with the least reproductive value) when lethal collection is necessary to improve the chances of the species survival
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The molecular synergy between these peptides occurs at multiple levels
So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations