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0.3 cm 3 /g) but was significantly underestimated by the DR method (0.103 cm 3 /g)

These non-genomic signals are mediated by membrane-associated receptors and can rapidly activate pathways such as extracellular signal-regulated kinase)/mitogen-activated protein kinase, protein kinase C (elevating intracellular Ca 2+ ), JNK/phosphatidylinositol 3 kinase, and cAMP-dependent transcription, which regulate critical cellular processes including apoptosis

These include recommendations for comprehensive physicochemical characterization, in vivo biodistribution studies, and detailed toxicological profiling