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The small intestinal epithelium is composed of villi that extend into the lumen and are lined by differentiated, post-mitotic cell types, and the crypts of Lieberkhn that contain Paneth cells and undifferentiated stem cells [16]

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The safety and effectiveness of continued long-term use in these individuals has not been established

Microbiome-targeted interventions like probiotics and diet have shown potential to modulate immune activity and may reduce disease activity, though more robust clinical evidence is needed