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Intracorporeal plaque (Peyronies plaques within the corpora) is a relatively rare type of the disease unless the patient receives PGE injections

10.1002/cphy.c120011 19 BoursierJ.MuellerO.BarretM.MachadoM.FizanneL.Araujo-PerezF.et al (2016)

Research confirms it maintains this selectivity even at extremely high dosages, ensuring that experimental observations reflect pure growth hormone signaling rather than multi-hormonal activation This molecular precision is critical for mechanistic research, where hormonal cross-activation, such as stimulation of the hypothalamic-pituitary-adrenal (HPA) axis, would otherwise confound the data

The analogy is imperfect, since topical application produces subtler and more gradual results, but the mechanism is related