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In preclinical models, its applied to cultured fibroblasts, epithelial tissues, and immune cells to study telomere dynamics, cell-cycle checkpoints, and oxidative-stress defensesall key processes in cellular aging

The Endocrine Society's clinical practice guideline on hypertriglyceridemia notes that "omega-3 fatty acids are appropriate first-line therapy for severe hypertriglyceridemia (500 mg/dL or above)" [10]

doi: 10.1016/j.it.2012.07.007 66 JiangTZhouCRenS

694,695 Furthermore, in the setting of diabetic myocardial IRI, melatonin effectively improves mitochondrial quality control, alleviates diabetic cardiomyopathy, and hence reduces myocardial vulnerability to IRI through the SIRT1-PGC-1 or AMPK-PGC-1 pathway