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[DOI] [PubMed] [Google Scholar] 20.Oliveira C., Coelho C., Teixeira J.A., Ferreira-Santos P., Botelho C.M

Experimental investigations show that senescent cells typically exhibit permanent cell cycle arrest mediated by p53/p21 signaling, creating a unique cellular state that depends on specific survival mechanisms for viability

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A meta-analysis conducted by Chen et al., consisting of 13 controlled clinical trials with 3512 participants, showed better efficacy of tailored therapies compared with empirically chosen regimens (Chen et al