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Scrophulariae Radix affects lipid metabolism

These GST enzymes catalyze the binding of synthesized glutathione to electrophilic xenobiotics (foreign chemicals), reactive drug metabolites, and environmental toxins, effectively neutralizing their threat

To investigate whether cells deficient in a SWI/SNF subunit other than ARID1A are sensitive to GSH inhibition, we first established a cancer cell line panel derived from SWI/SNF-proficient cell lines (HCC44, PC9, H2122, H2228), and from SMARCA4-deficient (H1819, H1703, H522, KP-4) 19,20 , SMARCB1-deficient (JMU-RTK-2, G401, G402, HS-ES-1), or PBRM1-deficient (RCC-MF, KMRC-1) cell lines (Fig

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