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A study showed that the high affinity and selectivity of stapled peptides were governed by the chemical structures of the staples by analyzing the obtained crystal structure, even a small change, which can trigger different binding modes with high affinity [134]

f , Volcano plot showing relative fold change (log 2 ) in IP protein abundance versus log 10 (adjusted P value) from HEK293T cells expressing ER-tag compared to those expressing control-tag (n = 3, P-value adjusted for 1% permutation-based FDR correction)

Grx activity depends on both GSH and GR for regeneration of GSH from GSSG, meaning this system is functionally dependent on the GSH system