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The low pH of vitamin C and strong acids can destabilise the peptide, and combining with retinoids in a single routine often produces unnecessary irritation

Endocrinology 147 , 28012808 (2006)

Reconstituted solution storage requires 2-8C refrigeration with critical light protection (keep in dark or wrapped in foil), in original vial with tight seal, avoiding repeated temperature cycling and never freezing reconstituted solution

The TRIUMPH-4 trial protocol provides the best reference for effective dosing : Weeks 1-4: 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 6 mg once weekly Weeks 13-16: 8 mg once weekly Week 17+: 9 mg or 12 mg once weekly (maintenance dose) The escalation happens every 4 weeks, which is slightly faster than many tirzepatide protocols