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This paradoxthat patients with higher baseline severity showed higher rates of MELD-3 improvementis compatible with several mechanisms, including (but not limited to) a possible therapeutic effect of glutathione in inflammation-rich states, control of the precipitating event by concurrent standard care, and statistical regression toward the mean

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Upon zinc supplementation, there is an increase in ZnT1 mRNA expression

Ethics declarations Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper