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Dimethyl itaconate activates innate immune defenses, maintains inflammatory homeostasis, activates STAT3 and autophagy, and exhibits strong antimycobacterial properties in both macrophages and in vivo models [102]
Subsequent studies confirmed a significant correlation between prolactin rhythm dysregulation and metabolic dysfunction ( Circadian rhythm misalignments, such as those imposed by jet lag, play an important role in the occurrence and progression of metabolic dysfunction-associated fatty liver disease ( In summary, an intact prolactin diurnal rhythm may play a crucial role in maintaining metabolic homeostasis, whereas its disruption is associated with impaired glucose homeostasis, adipose tissue dysfunction, and an increased risk of metabolic comorbidities
A Systematic Review
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