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Safety profile and important considerations Dihexa has a limited human safety dataset

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The evidence base consistently demonstrates that modest caloric restriction combined with regular exercise produces clinically significant weight loss and improves metabolic health markers

Studies looking at NR doses up to 2,000mg per day and NMN doses up to 1,200mg per day found no differences in adverse effects between intervention and placebo groups.31 4 In studies of higher doses that produced adverse effects, typical reactions included:32 Headache Dry mouth GI upset Muscle cramps or spasms As with many forms of vitamin B, NR can cause some flushing, and both NR and NMN can cause digestive upset