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111 Topical ivermectin (Sklice) is an antiparasitic medication that has been shown to reduce rosaceas papules and pustules by decreasing the presence of skin mites in the Demodex family, as well as suppressing inflammation

NLRP3 inhibitor Oridonin can suppress the expression of IL-18 and IL-1, alleviate inflammation, preserve myocardial function and improve myocardial remodeling by reducing NLRP3 expression [89]

EAE in bone marrow transplanted male animals was induced in anesthetized 810-week-old animals after irradiation by subcutaneous injection at the tail base of 10 g of recombinant rat MOG together with incomplete Freuds adjuvant 1:1 (Sigma, St Louis, MO)