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2d-f) and weighted (Supplementary Fig

Supporting a dominant role for diet composition in establishing the Firmicutes : Bacteroidetes ratio, previous work has shown that mice maintained on a high-fat diet had a similar cecal Firmicutes : Bacteroidetes ratio to those maintained on a high-carbohydrate diet 77

These properties are relevant given the established role of HGH in cartilage growth and repair through the local stimulation of IGF-1

The compound could also complement GH-class peptides by ensuring that fat cells have the metabolic machinery to oxidize the fatty acids that GH-mediated lipolysis mobilizes