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ECs repair after ischemic stroke involves migration, proliferation, tube formation, and restoration of barrier function, each subject to time-dependent regulation that influences the course of BBB recovery (57)

"Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding"

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The peptide is stable in gastric acid, which makes oral administration viable for gut-targeted applications, a property that distinguishes it from many other therapeutic peptides that degrade before reaching target tissue