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Improvement of major depression is associated with increased erythrocyte DHA

Nutritional optimization instead of supplementation Focusing on b12-rich foods may provide adequate amounts for many patients

It is important to note that such violations may suggest low oral bioavailability (due to high molecular weight or excessive lipophilicity), solubility limitations (reflected in Log S and TPSA values, leading to poor dissolution), inadequate permeability, an increased risk of toxicity or adverse effects, and/or a reduced likelihood of clinical success

Funding This work was supported by Science and Technology Planning Project of Guangdong Province of China (2014A020212188)