Thus, in general, drug absorption may be dissolution rate-limited or permeation rate-limited.
However, this review will not consider this further as it has already been addressed elsewhere (Wu et al., 2021
Since levothyroxine requires an acidic gastric environment for optimal dissolution and absorption, and its absorption can be affected by the rate of gastric emptying, patients may experience variations in thyroid hormone levels when starting semaglutide therapy
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