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In some cases, vacuolar peptidases may cleave the glutamate and glycine of the original glutathione molecule, leaving the cysteinyl conjugate (cysteine-X) which may need further processing in Phase III reactions, such as incorporation into cell wall material

This shift can contribute to gradual skin lightening

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Dexamethasone reduces acute tubular necrosis without improving renal failure To understand how these opposing mechanisms affect ferroptosis in complex pathophysiological settings, we next focused on acute kidney injury (AKI), which has been established as a standard model for ferroptotic cell death in vivo [9]