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An estrobolome enriched in beta-glucuronidase enzymes promotes estrogen metabolite deconjugation, resulting in greater reabsorption of free estrogens and higher risk of hormone receptor-positive cancers according to research published in the Journal of the National Cancer Institute

Therefore, the System Xc GSHGPX4 axis constitutes a complete and finely tuned antioxidant defense chain ( via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L