acetyl l carnitine 功效 Acetyl_L_carnitine_supplement_28c70912f6.png 乙酰左旋肉鹼──維護、保護和修復所需的重要物質| 健康中心

Bareggi SR, Cornelli U (2012) Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders

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Supplementation with riboflavin can act as a molecular chaperone, restoring structure and improving function in FAD-domain mutants (71)

Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]