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However, despite substantial progress, the precise molecular mechanisms governing ROS perception, signal transduction, and downstream gene regulation remain only partially understood

The safety and efficacy of several curcumin formulations are currently being explored in (pre)clinical settings with the aim of increasing the absorption, bioavailability, and tissue-targeted delivery of curcumin (12-16)

OR by adding a pinch of salt for each quart or liter of boiled water

The stratification into mechanistic subtypes, such as neuroinflammation-dominant, could be guided by biomarkers like specific cytokines (e.g., associations found between interleukin-6 and tinnitus intensity (Tanaka et al., 2024)) or by functional imaging with specific tracers