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In addition, oral use of purified neem seed extract has been found to be efficacious in pregnancy termination in both rodents and primates, as indicated by a total decline of chorionic gonadotropin and progesterone and by resumption of cyclic changes in hormone profiles and perineal sex swelling in baboons (Talwar et al., 1997)

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The skin acts as a reservoir, allowing the peptide to remain active in the local tissue for many hours, creating a prolonged local effect instead of a short systemic one