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Additionally, TMG is interesting because of its role in homocysteine

A common effect of all stress treatments was the accumulation of H 2 O 2 often accompanied by an increase in malondialdehyde (MDA) levels pointing to ROS-dependent oxidation of lipids

On the other hand, human and rodent neural progenitors differ in several intrinsic properties including growth requirements (Culbreth et al., 2012), timing of differentiation (Ostenfeld et al., 2002), expression of surface proteins such as aquaporins (Cavazzin et al., 2006), and sensitivity to various compounds (Malik et al., 2014)

Indeed, GO and KEGG pathway enrichment analyses revealed that the upregulated differentially expressed genes resulted from IPA treatment at D7 post-DSS administration were enriched in the pathways that are important in maintaining ISC niche and mucosal barrier function, including DNA replication, cell cycle, regulation of cell division and stem cell proliferation (Fig