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The host liver can be preconditioned by small molecules to create amicable hepatic microenvironments, including endothelial disruption, microcirculatory dilation, instant blood-mediated inflammatory reaction (IBMIR) inhibition, and cell proliferation, which favor the engraftment and repopulation of the transplanted hepatocytes

In some embodiments, the formulation or composition comprises between about 0.1% to about 80% by weight of the viscosity modulating agent

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Kawas C, Gray S, Brookmeyer R, Fozard J, Zonderman A