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Autophagy 20 , 114130 (2024)

By amplifying the natural nocturnal growth hormone pulse when administered before bed, Sermorelin enhances slow-wave sleep duration and depth, improves overall sleep architecture and continuity, reduces sleep fragmentation from spontaneous awakenings, and promotes more genuinely restorative rest that supports optimal daytime function

For instance, administration of UroA to Caenorhabditis elegans led to a significant extension of lifespan, while rodent studies showed enhanced muscle endurance and reduced signs of muscle ageing (Reference Ryu, Mouchiroud and Andreux15)

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