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When BCAT 2 is knocked down, depletion of BCKAs and its derivative acetyl-CoA promotes WAT brown steatosis and energy expenditure

Several studies in IgAN animal models have reported a decreased abundance of beneficial bacteria, including Bifidobacterium , Oscillospira , Roseburia , Turicibacter , and Dubosiella [141-143], along with increased levels of pathogenic bacteria, such as Helicobacter , Alloprevotella , Shigella sonnei , Streptococcus danieliae , Desulfovibrio fairfieldensis , and Candidatus Arthromitus [141, 142]