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NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)

D51.3 Other Dietary Vitamin B12 Deficiency Anemia Use for B12 deficiency caused by dietary inadequacy, most commonly seen in strict vegans or vegetarians with no dairy or egg intake, and in elderly patients with poor nutritional intake

These materials are not drugs, medications, dietary supplements, or medical products and have not been evaluated or approved by the U.S

The B12 intravenous dose is usually the same as the intramuscular dose, from 1000 mcg to 2500 mcg per infusion